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Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
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Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

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[Gastro-intestinal disorders in premature neonates receiving early enteral feeding (author's transl)]

A Chantepie, F Gold, C Maurage

    Archives Francaises De Pediatrie
    |February 1, 1982
    PubMed

    Insights

    Early enteral feeding is safe for most premature infants, even those at risk for gastro-intestinal (G-I) disorders. Feeding should be carefully monitored, with temporary interruption advised for low birth weight infants experiencing asphyxia.

    Area of Science:

    • Neonatal Medicine
    • Gastroenterology
    • Pediatric Surgery

    Context:

    • Gastro-intestinal (G-I) disorders are a concern in premature neonates.
    • Mesenteric ischemia symptoms were present in 95 studied premature infants.
    • Early feeding with tyndallized maternal milk was common in this cohort.

    Purpose:

    • To investigate the incidence and risk factors of G-I disorders, including necrotizing enterocolitis (NEC), in premature neonates.
    • To evaluate the safety and efficacy of early enteral feeding in at-risk premature infants.

    Summary:

    • No definitive necrotizing enterocolitis (NEC) was diagnosed in 95 premature neonates, though suspected in 4.2% and minor changes in 7.3%.
    • Low birth weight (<1,500 gm) and secondary apnea/asphyxia during mechanical ventilation were correlated with G-I disorders.
    • Early enteral feeding is recommended for high-risk prematures due to low severe G-I impairment incidence and feeding benefits, with careful symptom monitoring.

    Impact:

    • Informs clinical practice regarding feeding strategies for premature infants.
    • Highlights the importance of monitoring G-I symptoms and considering asphyxia events.
    • Supports the continuation of early enteral feeding while managing risks in vulnerable neonates.

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