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Thyroid function in 44 patients with amyotrophic lateral sclerosis.

W R Kiessling

    Archives of Neurology
    |April 1, 1982
    PubMed
    Summary
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    Thyroid function tests in amyotrophic lateral sclerosis (ALS) patients revealed normal thyroid status. This suggests that thyroid function is unlikely to be a contributing factor in the development of ALS, even in areas with high goiter incidence.

    Area of Science:

    • Neurology
    • Endocrinology
    • Thyroid Research

    Background:

    • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with unknown etiology.
    • Endemic goiter areas present unique challenges for understanding thyroid-related conditions.
    • Previous research has not definitively linked thyroid dysfunction to ALS pathogenesis.

    Purpose of the Study:

    • To investigate thyroid function in patients diagnosed with amyotrophic lateral sclerosis (ALS).
    • To determine if thyroid abnormalities or anti-thyroid antibodies are associated with ALS.
    • To assess the relevance of thyroid status to ALS development in an endemic goiter region.

    Main Methods:

    • Radioimmunoassay was used to measure triiodothyronine, thyroxine, thyroxine-binding globulin, and thyroid-stimulating hormone levels.

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  • Protirelin stimulation tests were conducted to evaluate thyroid-stimulating hormone response.
  • Hemagglutination techniques were employed to detect circulating anti-thyroid antibodies.
  • Clinical examinations included assessment for goiter in all participants.

    • Main Results:

    • All 44 ALS patients evaluated were found to be euthyroid, indicating normal thyroid function.
    • No patients tested positive for circulating anti-thyroid antibodies.
    • A significant proportion of patients (36%) presented with a concomitant goiter.
    • Thyroid function parameters remained within normal ranges despite the presence of goiter in some patients.

    Conclusions:

    • The study suggests that abnormal thyroid status is not a significant factor in the pathogenesis of amyotrophic lateral sclerosis (ALS).
    • The findings indicate that ALS can occur in euthyroid individuals, even in regions with a high prevalence of goiter.
    • Further research may be needed to explore other potential etiological factors for ALS.