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Related Experiment Videos

Benoxaprofen: side-effect profile in 300 patients.

J P Halsey, N Cardoe

    British Medical Journal (Clinical Research Ed.)
    |May 8, 1982
    PubMed
    Summary

    Benoxaprofen caused significant side effects in 65.3% of patients, leading to drug withdrawal in 34.6%. Elderly patients over 70 experienced higher rates of adverse events, particularly photosensitivity.

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    Area of Science:

    • Pharmacology
    • Dermatology
    • Geriatrics

    Background:

    • Benoxaprofen is a non-steroidal anti-inflammatory drug (NSAID).
    • NSAIDs are commonly prescribed for inflammatory conditions.
    • Understanding drug-induced side effects is crucial for patient safety.

    Purpose of the Study:

    • To evaluate the incidence and types of side effects associated with benoxaprofen use.
    • To assess the safety profile of benoxaprofen, particularly in elderly patients.
    • To determine the rate of drug withdrawal due to adverse events.

    Main Methods:

    • A cohort of 300 patients treated with benoxaprofen was monitored.
    • Data on reported side effects, including type and severity, were collected.
    • Patient demographics, particularly age, were analyzed in relation to side effect incidence.

    Main Results:

    • 65.3% of patients reported side effects, with 34.6% discontinuing the drug.
    • Photosensitivity was the most common cutaneous side effect (28.6%).
    • Elderly patients (>70 years) showed higher incidence of side effects (83.3%) and withdrawal (69.0%), with increased gastric side effects (40.5%).

    Conclusions:

    • Benoxaprofen is a potent phototoxic drug.
    • The recommended dosage is associated with an unacceptable incidence of side effects, especially in the elderly.
    • Adverse events necessitate careful patient monitoring and consideration of alternative treatments.

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