Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple myeloma protein with three light chains.

T Sun, R B Erichson, Y Y Lien

    Clinical Chemistry
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2011
    Same author

    Fabrication and characterization of high-T(c) YBa(2)Cu(3)O(7-x) nanoSQUIDs made by focused ion beam milling.

    Nanotechnology·2011
    Same author

    Thigh muscle volume predicted by anthropometric measurements and correlated with physical function in the older adults.

    The journal of nutrition, health & aging·2011
    Same author

    Effects of operational parameters on decolorisation of C.I. Reactive Black 5 in UV/TiO(2) system.

    Water science and technology : a journal of the International Association on Water Pollution Research·2011
    Same author

    cDNA cloning by inverse polymerase chain reaction.

    Methods in molecular biology (Clifton, N.J.)·2011
    Same author

    Progress toward a synthetic virus : a multicomponent system for liver-directed DNA delivery.

    Methods in molecular medicine·2011

    This study details a rare case of immunoglobulin G (kappa) myeloma where excess kappa light chains formed a transient complex with alpha 1-antitrypsin in the blood. This finding is associated with high urinary kappa chain excretion in myeloma patients.

    Area of Science:

    • Immunology
    • Oncology
    • Biochemistry

    Background:

    • Multiple myeloma is a cancer of plasma cells, often characterized by the overproduction of a single type of immunoglobulin (M-protein).
    • Kappa and lambda are the two types of immunoglobulin light chains, and their imbalance can indicate underlying plasma cell disorders.

    Observation:

    • A patient with immunoglobulin G (kappa) myeloma presented with both a monoclonal IgG(kappa) arc and excess free kappa light chains in the serum.
    • Urine analysis revealed significant excretion of kappa chains (7.75 g/L).

    Findings:

    • Immunoelectrophoresis and immunodiffusion identified an electrophoretically fast-moving kappa chain in the serum as a complex of kappa light chains and alpha 1-antitrypsin.
    • This kappa chain-alpha 1-antitrypsin complex was transient and formed via a disulfide bond between monomeric kappa chains and alpha 1-antitrypsin.

    Related Experiment Videos

  • The formation of this complex appears linked to kappa-type myeloma protein and high urinary kappa chain levels (>1 g/L).

    • Implications:

    • This transient complex represents a novel biochemical finding in certain myeloma cases, potentially serving as a diagnostic or prognostic marker.
    • Further research is needed to elucidate the predisposing factors for complex formation and its relationship with myeloma treatment (chemotherapy).