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The ageing ovary.

P O Janson, B Dennefors, L Hamberger

    Acta Obstetricia Et Gynecologica Scandinavica. Supplement
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    The ageing ovary undergoes endocrine changes, with defective follicular function during perimenopause and continued steroid secretion by stromal cells postmenopause. These changes can occasionally lead to symptoms like hirsutism.

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    Area of Science:

    • Reproductive Endocrinology
    • Gerontology
    • Gynecology

    Background:

    • Ageing ovaries exhibit altered endocrine function.
    • Perimenopausal changes include defective follicular activity, leading to irregular cycles and anovulation.
    • Postmenopausal ovaries retain stromal cells that secrete steroids, primarily androgens.

    Purpose of the Study:

    • To review the endocrine function of the ageing ovary.
    • To describe the hormonal changes during perimenopause and postmenopause.
    • To correlate ovarian endocrine activity with clinical manifestations.

    Main Methods:

    • Literature review of studies on ovarian endocrine function in ageing women.

    Main Results:

    Related Experiment Videos

  • Perimenopause is characterized by impaired follicular function, resulting in cycle variability and anovulation.
  • Postmenopausal ovarian stromal cells secrete androgens, though typically at levels not causing symptoms.
  • Rare instances of hirsutism and virilization are associated with non-neoplastic ovarian lesions in postmenopausal women.

    • Conclusions:

    • The endocrine function of the ageing ovary changes significantly throughout perimenopause and postmenopause.
    • While generally low, postmenopausal ovarian steroid secretion can occasionally manifest clinically.
    • Non-neoplastic ovarian lesions may contribute to androgen excess in postmenopausal women.