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Related Experiment Videos

Training dose as a factor in LSD-saline discrimination.

F J White, J B Appel

    Psychopharmacology
    |January 1, 1982
    PubMed
    Summary
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    Training dose impacts lysergic acid diethylamide (LSD) stimulus properties in rats. Serotonin (5-HT) mediates LSD effects, while dopamine (DA) does not appear involved.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • The discriminative stimulus properties of drugs are crucial for understanding their central nervous system effects.
    • Lysergic acid diethylamide (LSD) is a potent psychoactive substance with complex neurochemical interactions.

    Purpose of the Study:

    • To investigate how different training doses of LSD influence its discriminative stimulus properties in rats.
    • To elucidate the roles of serotonin (5-HT) and dopamine (DA) in mediating LSD's stimulus effects.

    Main Methods:

    • Rats were trained to discriminate between LSD and saline using a dose-fading technique.
    • Dose-response, substitution, and antagonism tests were conducted using various 5-HT and DA receptor agonists and antagonists.

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    Main Results:

    • LSD stimulus cues were dose-specific to training, with lower training doses resulting in less steep dose-response curves.
    • Serotonin (5-HT) agonists and antagonists demonstrated 5-HT's involvement in LSD's in vivo effects, modulated by training dose.
    • Peripheral serotonergic actions may contribute to low-dose LSD cues, while dopamine (DA) showed no significant involvement.

    Conclusions:

    • Training dose is a critical factor in shaping the discriminative stimulus properties of LSD.
    • Serotonergic pathways, including peripheral actions at low doses, are key mediators of LSD's stimulus effects.
    • Dopamine (DA) does not appear to play a significant role in the discriminative stimulus properties of LSD.