Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sedative-hypnotics and human performance.

L C Johnson, D A Chernik

    Psychopharmacology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Sedative-hypnotic drugs impair next-day performance, especially at higher doses. These effects can persist throughout the day, with little evidence of improvement in cognitive functioning.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Determining the effect of cardiac blood volume on accuracy of uptake rate constants by simulation.

    Physics in medicine and biology·2023
    Same author

    The Practical Haplotype Graph, a platform for storing and using pangenomes for imputation.

    Bioinformatics (Oxford, England)·2022
    Same author

    Development and feasibility of quantitative dynamic cardiac imaging for mice using μSPECT.

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2020
    Same author

    Effects of drainage and temperature on carbon balance of tussock tundra micrososms.

    Oecologia·2017
    Same author

    Effect of pinhole shape on projection resolution.

    Physics in medicine and biology·2016
    Same author

    Commentaries on Viewpoint: Can elite athletes benefit from dietary nitrate supplementation?

    Journal of applied physiology (Bethesda, Md. : 1985)·2015
    Same journal

    OPRD1 rs4654327 and Outcomes of Extended-Release Naltrexone in Alcohol Use Disorder: An Exploratory Prospective Pharmacogenetic Study.

    Psychopharmacology·2026
    Same journal

    Comparative effects of inactivation and dopamine receptor agents in the dorsolateral and dorsomedial striatum on performance of action sequences in rats.

    Psychopharmacology·2026
    Same journal

    Peripheral oxytocin administration decreases the food intake and compulsive-like behavior in male rats in an animal model of binge-type eating.

    Psychopharmacology·2026
    Same journal

    Beyond cannabis use severity: associations of cannabis product type with sleep quality and mental health.

    Psychopharmacology·2026
    Same journal

    The relationship between duration of access to intravenous oxycodone self-administration, economic demand for oxycodone, and cognition in rats.

    Psychopharmacology·2026
    Same journal

    Effects of repeated low-dose LSD on neuropsychological functioning in adults with ADHD: a randomized placebo-controlled study.

    Psychopharmacology·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Sleep Medicine

    Background:

    • Sedative-hypnotic medications are widely prescribed for sleep disorders.
    • Previous research indicates potential next-day impairment from these drugs.
    • Limited data exist on the impact on cognitive functions and complex behaviors.

    Purpose of the Study:

    • To systematically review the impact of sedative-hypnotic medications on next-day performance.
    • To evaluate the consistency of performance decrements across different drug classes and doses.
    • To identify gaps in the research regarding cognitive and behavioral effects.

    Main Methods:

    • Meta-analysis of 52 studies comparing sedative-hypnotic ingestion to placebo.
    • Focus on performance data collected the day after bedtime administration.

    Related Experiment Videos

  • Analysis of drug class (primarily benzodiazepines) and dose-dependency.

    • Main Results:

    • No drug-related performance improvements were observed.
    • All tested hypnotics demonstrated performance decrements at certain doses compared to placebo.
    • Higher doses consistently led to persistent performance decrements throughout the day.
    • Longer-acting drugs generally showed greater impairment, though half-life data were inconsistent.

    Conclusions:

    • Sedative-hypnotics consistently impair next-day psychomotor performance.
    • Dose and drug half-life are critical factors influencing the duration and severity of impairment.
    • Further research is needed on cognitive and complex behavioral effects, particularly in patient populations.