[Activation of the antihemophilic globulin A (factor VIII). 3. Activation by servalyte]

A series of ampholytes is investigated concerning its influence on the activity of factor VIII. While positively charged ampholine (polyamino-polycarboxylic acids) may increase the activity of factor VIII, positively charged amino acids and dipeptides do not have this property. A group of substances (servalyte) constructed similarly to ampholine which besides amino groups and carboxyl groups has as charge carriers also phosphate and sulphate groups increases the activity of factor VIII like ampholine. Obviously not only the net charge of the molecule plays an essential role in the influence on the activity of factor VIII, but also size and configuration.