Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrauterine pressure changes during dysmenorrhea therapy.

R P Smith, J R Powell

    American Journal of Obstetrics and Gynecology
    |June 1, 1982
    PubMed
    Summary

    Mefenamic acid effectively treats spasmodic dysmenorrhea by significantly reducing uterine pressure and activity. This prostaglandin inhibitor provided complete relief for nearly half of patients and subjective relief for all.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hippocampal Dosimetry and Implication for Treatment Planning in Patients Undergoing Stereotactic Radiosurgery for Limited Brain Metastases.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2026
    Same author

    Do GLP-1RAs and SGLT-2is reduce cardiovascular events in women with type 2 diabetes? A systematic review and meta-analysis.

    Diabetes & metabolism·2020
    Same author

    Patient Involvement in the Design of a Randomised Trial of Proton Beam Radiotherapy Versus Standard Radiotherapy for Good Prognosis Glioma.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2019
    Same author

    Comparing once-weekly semaglutide to incretin-based therapies in patients with type 2 diabetes: a systematic review and meta-analysis.

    Diabetes & metabolism·2018
    Same author

    Infection rate of <i>Aedes aegypti</i> mosquitoes with dengue virus depends on the interaction between temperature and mosquito genotype.

    Proceedings. Biological sciences·2017
    Same author

    POPULATION GENETICS OF MEXICAN DROSOPHILA VI. CYTOGENETIC ASPECTS OF THE INVERSION POLYMORPHISM IN DROSOPHILA PSEUDOOBSCURA.

    Evolution; international journal of organic evolution·2017

    Area of Science:

    • Pharmacology
    • Gynecology
    • Physiology

    Background:

    • Primary spasmodic dysmenorrhea treatment is evolving.
    • Prostaglandin synthetase/receptor site inhibitors are increasingly accepted therapies.
    • Advancements in intrauterine pressure recording enable objective data collection.

    Purpose of the Study:

    • To objectively evaluate the effectiveness of mefenamic acid in treating primary spasmodic dysmenorrhea.
    • To assess the impact of mefenamic acid on uterine pressure and contractile activity.
    • To correlate objective findings with subjective patient relief.

    Main Methods:

    • Utilized improved intrauterine pressure recording for physiologic data acquisition.
    • Administered mefenamic acid (Ponstel) to patients with primary spasmodic dysmenorrhea.
    • Combined objective pressure data with subjective patient-reported outcomes.

    Main Results:

    • Mefenamic acid demonstrated rapid and significant reductions in uterine pressure and work.
    • Complete cessation of uterine contractile activity was observed in 46.2% of patients.
    • All patients receiving mefenamic acid reported subjective relief.

    Conclusions:

    • Mefenamic acid is an effective treatment for primary spasmodic dysmenorrhea.
    • The drug markedly reduces uterine pressure and contractile activity.
    • Objective data support the significant subjective pain relief experienced by patients.

    Related Experiment Videos