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Animal models for alcohol research.

H L Altshuler

    Currents in Alcoholism
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Animal models are crucial for alcoholism research, but no single model fits all needs. This review categorizes chronic, reinforcement, and genetic models, detailing their strengths, weaknesses, and applications for effective research design.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Alcoholism research utilizes diverse animal models.
    • No single animal model fully captures the complexity of alcohol abuse.
    • Effective research requires careful selection and application of appropriate models.

    Purpose of the Study:

    • To review and categorize existing animal models for alcoholism research.
    • To discuss the strengths, weaknesses, and applications of different model classes.
    • To highlight challenges in model selection and control for alcoholism studies.

    Main Methods:

    • Categorization of animal models into chronic, reinforcement, and genetic groups.
    • Discussion of the premises, experimental applications, strengths, and limitations of each model class.

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  • Analysis of control issues in alcoholism research, particularly dual controls for caloric and pharmacological effects.

    • Main Results:

    • Animal models for alcoholism research can be broadly classified into chronic, reinforcement, and genetic types.
    • Each model class possesses unique advantages and disadvantages for studying alcohol's actions and abuse.
    • Appropriate controls, accounting for both caloric and pharmacological effects of alcohol, are essential but challenging to implement.

    Conclusions:

    • The diversity of alcoholism necessitates a range of animal models.
    • Careful selection and appropriate use of animal models are critical for credible alcoholism research.
    • Addressing challenges in experimental design, especially control groups, is vital for advancing our understanding of alcohol use disorder.