Adrenergic and non-adrenergic inhibitory nerves in mammalian airways

A study of the actions of adrenergic and non-adrenergic nerves which affect mammalian airways was carried out. The preparations studied included strips of lung from guinea-pig, rat, rabbit, monkey and human, tracheal strips from the first 4 animals and bronchial strips from the last 3. Relaxations to field stimulation of sympathetic nerves were found in the guinea-pig trachea only. Functional nonadrenergic inhibitory nerves were found in the larger airways of all species except rat. Lung strips from all the mammals failed to respond to sympathetic or nonadrenergic inhibitory nerve stimulation suggesting a lack of functional inhibitory nerves of either type in the fine airways. Studies on the distribution of adrenergic nerves showed that primary target of the nerves in all species appeared to be the vasculature, especially in lung. Occasional fibres were seen entering the smooth muscle of the fine airways in guinea-pig, rabbit, and rat, but not in monkey or human lung or in monkey trachea or bronchus or human bronchus. Guinea-pig and rabbit trachealis muscles received a significant innervation but only the guinea-pig tissue responded to sympathetic stimulation. Inhibitory beta-adrenoceptors were demonstrated in the proximal airways of all species except rabbit. The fine airways of rat, monkey and human contained a mixed population of alpha-excitatory and beta-inhibitory adrenoceptors only were found in guinea-pig lung and alpha-adrenoceptors only in rabbit lung.