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Related Experiment Videos

Pituitary and thyroid function in male cynomolgus monkeys.

R C Smallridge, I Mehlman, C L Pamplin

    Laboratory Animal Science
    |December 1, 1981
    PubMed
    Summary

    This study characterizes thyroid hormone kinetics in cynomolgus monkeys, finding non-linear hormone disappearance and establishing baseline levels for thyrotropin and prolactin. Dexamethasone did not significantly alter thyrotropin levels.

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    Area of Science:

    • Endocrinology
    • Primate Physiology
    • Pharmacology

    Background:

    • Thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are crucial for regulating metabolism.
    • Understanding their kinetics and the impact of exogenous substances is vital in preclinical research.
    • Cynomolgus monkeys serve as a relevant model for human physiological studies.

    Purpose of the Study:

    • To determine the serum levels and kinetic parameters of T4 and T3 in male cynomolgus monkeys.
    • To assess the baseline and stimulated levels of thyrotropin (TSH) and prolactin in response to thyrotropin-releasing hormone (TRH).
    • To investigate the effect of chronic dexamethasone administration on TSH and prolactin secretion.

    Main Methods:

    • Serum T4 and T3 concentrations were measured.

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  • Radioisotope kinetic studies using 131I-T4 and 125I-T3 were performed to determine hormone clearance and production rates.
  • Blood samples were collected at baseline and after TRH administration to measure TSH and prolactin.
  • Hormone levels were assessed before and after a 5.5-month course of dexamethasone therapy.

    • Main Results:

    • Non-linear, biexponential disappearance curves were observed for both T4 and T3.
    • Metabolic clearance rates (MCR) and production rates (PR) were established for T4 and T3.
    • Baseline TSH and prolactin levels were determined, with significant increases observed post-TRH stimulation.
    • Chronic dexamethasone therapy showed a trend towards lower TSH levels, but this was not statistically significant.

    Conclusions:

    • Cynomolgus monkeys exhibit distinct T4 and T3 kinetic profiles.
    • TRH effectively stimulates TSH and prolactin release in this species.
    • Chronic dexamethasone administration does not significantly suppress the TSH response to TRH in cynomolgus monkeys.