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A regional external quality assessment scheme for serum thyroxine-binding globulin
Annals of Clinical Biochemistry
|May 1, 1982
Summary
External quality assessment for serum thyroxine binding globulin (TBG) assays shows comparable results across methods with a common calibrant. However, the lack of a universal TBG calibrant leads to significant result variance.
Area of Science:
- Clinical Chemistry
- Immunochemistry
- Laboratory Medicine
Background:
- Thyroxine binding globulin (TBG) is crucial for thyroid hormone transport.
- Accurate TBG measurement is essential for diagnosing thyroid disorders.
- External Quality Assessment (EQA) schemes are vital for monitoring assay performance.
Purpose of the Study:
- To present the results of a regional External Quality Assessment Scheme for serum TBG assays.
- To evaluate the comparability of different analytical methods for TBG determination.
- To identify sources of variance in TBG measurements.
Main Methods:
- Utilized a Regional External Quality Assessment Scheme.
- Analyzed serum samples for thyroxine binding globulin (TBG) concentration.
- Compared results from various analytical methods including rocket immuno-electrophoresis, radioimmunoassay, and radial immunodiffusion.
Main Results:
- Different analytical methods (rocket immuno-electrophoresis, radioimmunoassay, radial immunodiffusion) yielded comparable results when using a common calibrant.
- Significant variance in reported TBG results (in mg/l) was observed across different assay systems.
- The absence of a universally agreed-upon calibrant for TBG contributes to the observed discrepancies.
Conclusions:
- Standardization of calibration is necessary to reduce variability in TBG assays.
- Further efforts are needed to establish a universal calibrant for consistent TBG measurement.
- EQA schemes highlight the need for harmonization in laboratory diagnostics for thyroid-related proteins.