Related Experiment Videos
Effect of cimetidine on gonadal function in man
British Journal of Clinical Pharmacology
|June 1, 1982
Summary
Cimetidine therapy for duodenal ulcers increased testosterone and follicle-stimulating hormone (FSH) levels in men. However, it also decreased sperm count, impacting male reproductive health.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Gastroenterology
Background:
- Cimetidine is a histamine H2 receptor antagonist commonly used for treating acid-related gastrointestinal disorders.
- Potential endocrine and reproductive side effects of cimetidine warrant further investigation, particularly concerning male gonadal function.
Purpose of the Study:
- To investigate the impact of cimetidine on key hormonal parameters and sperm characteristics in male subjects with chronic duodenal ulcers.
Main Methods:
- Eleven male subjects with chronic duodenal ulcers received oral cimetidine (1000 mg/day for 3 months, then 400 mg nocte for 3 months).
- Hormonal levels (testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL)) and sperm parameters (count, motility, morphology) were assessed during and after treatment.
Main Results:
- Testosterone levels were elevated during cimetidine therapy compared to pre- and post-treatment.
- Serum FSH levels increased during therapy, while LH remained unchanged.
- Five subjects showed increased serum PRL levels; mean sperm count decreased during therapy but motility and morphology were unaffected.
Conclusions:
- Cimetidine therapy in men with duodenal ulcers can lead to hormonal alterations, including elevated testosterone and FSH, and potentially increased PRL.
- A significant decrease in sperm count was observed during cimetidine treatment, suggesting a potential impact on male fertility.
- Further research is recommended to elucidate the mechanisms behind these effects and their clinical significance.