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A new proteinaceous factor participating in the rat ejaculate coagulation--identification, isolation and function.

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|June 1, 1982

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Researchers identified a novel protein in male rats crucial for seminal fluid coagulation. This testicular protein

Area of Science:

Reproductive biology
Protein biochemistry
Andrology

Background:

Seminal vesicle secretion contains basic proteins.
A previously unrecognized protein substance is found in male reproductive tissues and serum.
This protein is associated with spermatozoa.

Purpose of the Study:

To identify and isolate a protein involved in seminal vesicle protein coagulation.
To determine the origin and characteristics of this novel protein.
To investigate the protein's role in the function of epididymal spermatozoa.

Main Methods:

Isolation and identification of the protein substance.
Analysis of protein concentration in serum, testes, and epididymides.
Age-dependency and castration studies.

Related Experiment Videos

In vitro assays for coagulation activity.

Main Results:

A protein (MW ~163,000) was isolated from serum, testes, epididymides, and spermatozoa.
Protein concentration is age-dependent, peaking in mature males, and decreases post-castration.
This protein is essential for the in vitro coagulation of seminal vesicle proteins by epididymal spermatozoa.

Conclusions:

A novel, testicular protein is identified, playing a key role in male reproductive physiology.
The protein's presence on spermatozoa is vital for seminal fluid coagulation.
This discovery offers insights into male fertility and reproductive processes.