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Related Experiment Videos

Diffusion of nitrosamines through protective gloves.

T A Gough, K S Webb, M F McPhail

    IARC Scientific Publications
    |January 1, 1978
    PubMed
    Summary
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    Protective gloves allow volatile nitrosamines to permeate, with N-nitrosopyrrolidine (NPYR) showing the highest permeability through both rubber and polyvinyl chloride (PVC) materials.

    Area of Science:

    • Occupational Health
    • Chemical Safety
    • Toxicology

    Background:

    • Volatile nitrosamines are a class of chemicals with known carcinogenic potential.
    • Protective gloves are commonly used to prevent dermal exposure to hazardous substances.
    • The permeability of glove materials to specific volatile nitrosamines requires thorough investigation.

    Purpose of the Study:

    • To experimentally assess the permeability of common protective glove materials to volatile nitrosamines.
    • To quantify the extent and rate of permeation for different nitrosamine compounds.
    • To determine if glove materials themselves are a source of nitrosamine contamination.

    Main Methods:

    • Rubber and polyvinyl chloride (PVC) gloves were inverted and filled with nitrosamine solutions in hexane.

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  • The outer surfaces of the glove fingers were washed with water at timed intervals.
  • Nitrosamine concentrations in the washings were measured to calculate permeation rates.

    • Main Results:

    • N-nitrosopyrrolidine (NPYR) demonstrated the highest and fastest permeation through both rubber and PVC gloves.
    • N-nitrosodibutylamine (NDBA) showed significantly lower permeation.
    • Analysis confirmed that the tested rubber gloves were free from common volatile nitrosamines.

    Conclusions:

    • Standard protective gloves offer limited protection against certain volatile nitrosamines, particularly NPYR.
    • Glove material selection is critical for effective protection against specific chemical hazards.
    • The study highlights the need for careful material selection and handling procedures to minimize nitrosamine exposure risks.