[Calmodulin regulation of intestinal epithelium adenylate cyclase (author's transl)]

Calmodulin stimulation of intestinal adenylate cyclase was evidenced in plasma membranes from isolated Rat intestinal epithelial cells. In the presence of free calcium, 10(-7) M calmodulin significantly stimulates intestinal enzyme activity and the maximal effect is induced by 10(-5) M calmodulin. Trifluoperazine, a specific calmodulin inhibitor suppresses this effect. These results suggest that calcium, via calmodulin, plays an important role in the regulation of cyclic AMP production in intestinal epithelium.