Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence for pulmonary CO2 chemosensitivity: effects on ventilation.

M I Sheldon, J F Green

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |May 1, 1982
    PubMed
    Summary

    This study investigated a pulmonary chemoreceptor for carbon dioxide (CO2) influencing spontaneous ventilation (VE). Results indicate a lung CO2 chemoreceptor that interacts with other receptors to control breathing.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Management of debilitating injuries in a large industrial setting.

    Journal of back and musculoskeletal rehabilitation·2014
    Same author

    The differential effects of chlorpromazine and haloperidol on latent inhibition in healthy volunteers.

    Journal of psychopharmacology (Oxford, England)·2001
    Same author

    An overview of the anatomy and physiology of slowly adapting pulmonary stretch receptors.

    Respiration physiology·2001
    Same author

    Vertical fixation disparity curve and the effects of vergence training in a normal young adult population.

    Optometry and vision science : official publication of the American Academy of Optometry·2001
    Same author

    Antisaccade and smooth pursuit eye movements in healthy subjects receiving sertraline and lorazepam.

    Journal of psychopharmacology (Oxford, England)·2000
    Same author

    Interaction of vagal lung afferents with inhalation of histamine aerosol in anesthetized dogs.

    Lung·2000

    Area of Science:

    • Physiology
    • Respiratory System Regulation
    • Chemoreception

    Background:

    • The control of spontaneous ventilation (VE) is complex, involving both central and peripheral chemoreceptors.
    • The role of pulmonary chemoreceptors, specifically for carbon dioxide (CO2), in regulating VE remains incompletely understood.

    Purpose of the Study:

    • To determine the existence and function of a pulmonary chemoreceptor for CO2 that influences spontaneous ventilation (VE).
    • To investigate the interaction between pulmonary and non-pulmonary chemoreceptors in the control of breathing.

    Main Methods:

    • Systemic and pulmonary circulations were separated in dogs under hyperoxic conditions.
    • Partial pressure of CO2 (PCO2) was independently controlled in each circuit.
    • Spontaneous ventilation (VE) was measured while systemic PCO2 (PSCO2) was held constant and pulmonary PCO2 (PpCO2) was varied.

    Related Experiment Videos

    Main Results:

    • Increasing pulmonary PCO2 (PpCO2) led to a significant increase in spontaneous ventilation (VE) when systemic PCO2 (PSCO2) was maintained at higher levels.
    • The response of VE to changes in PpCO2 was abolished when PSCO2 dropped below 25-30 Torr, resulting in apnea.
    • The observed effect of PpCO2 on VE was eliminated by vagotomy, suggesting involvement of vagal afferents.

    Conclusions:

    • These findings strongly suggest the presence of a CO2-sensitive chemoreceptor located within the lungs.
    • This pulmonary CO2 chemoreceptor appears to interact with non-pulmonary chemoreceptors in the overall regulation of spontaneous ventilation (VE).