[Acute neurological complications following intrathecal fluorescein injection (author's transl)]

This report describes two cases of grand mal seizures following intrathecal injection of fluorescein to delineate CSF-leakage. Recurrent phases of apnea necessitated artificial ventilation in one case. The results of CSF and serum investigations are discussed as well as EEG and EMG findings. As fluorescein has proved to be a potentially epileptogenic drug, its use for patients with a past history of seizures should be very carefully considered. All patients having received intrathecal fluorescein should be kept under observation for at least 4 to 6 hours.