[Determination of cis-diamminedichloroplatinum compound toxicity in pigs from the viewpoint of pathomorphology]

The study is a part of the clinical testing of the cytostatic preparation PLATIDIAM --Lachema with cis-diammine-dichloroplatinum complex (cis/DDP) as an active ingredient. The organs and tissues of 18 test pigs weighing 31 to 55 kg were subjected to the patho-morphological examination. The animals had been given experimentally the test cytostatic preparation Platidiam at a rate of 2.5 and 4.0 mg cis-DDP per kg 1. w. with and without hydration of their organisms. Severe changes were recorded in the kidneys of the pigs given the toxic doses of cis-DDP (4 mg/kg l. w.). The most frequent finding was that of cylindrical protein blocks in renal tubules combined with hyalinization of tubule cells. Optical microscopy of marrow showed vacuolization of epithelium and peeling off of epithelium layers. In some cases the dystrophic changes in renal tubules even led to necrotization of epithelium. No such changes were observed in the remaining animals given the therapeutic doses (2.5 mg/kg l. w.) nor in the controls. The findings on other organs cannot be associated with the toxicity of cis/DDP.