Multicenter trial of acyclovir and trifluorothymidine in herpetic keratitis

Acyclovir 3 percent ophthalmic ointment was compared with trifluorothymidine 2 percent ointment in a double-blind trial of 59 herpes keratitis patients. Clinical progress was measured by direct clinical assessment and retrospective photographic evaluation. Ninety percent of acyclovir-treated patients and 75 percent of trifluorothymidine-treated patients had healed within 14 days. There was no significant difference in the rate of healing between the two treatment groups.