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Septicaemia due to Yersinia enterocolitica after oral overdoses of iron
British Medical Journal (Clinical Research Ed.)
|August 14, 1982
Abstract:
Septicaemia occurred after accidental oral overdoses of iron in two previously healthy children. Yersinia enterocolitica serotype 0:3 was recovered from blood and stool cultures in both patients. Enhanced growth of Y enterocolitica in the intestine combined with damage of intestinal mucosa may have been of major importance for the development of generalised infection in these cases. Iron and the iron chelating agent desferrioxamine may possibly have a pathogenetic role in such circumstances.
Insights
Accidental iron overdose in children led to Yersinia enterocolitica septicaemia. Excess iron may promote bacterial growth and intestinal damage, contributing to severe infections.
Area of Science:
- Pediatric Infectious Diseases
- Gastroenterology
- Toxicology
Background:
- Iron overdose is a common pediatric poisoning, potentially leading to severe gastrointestinal complications.
- Yersinia enterocolitica is an opportunistic pathogen that can cause systemic infections.
Observation:
- Two healthy children developed septicaemia following accidental oral iron overdoses.
- Yersinia enterocolitica serotype 0:3 was isolated from blood and stool cultures in both cases.
Findings:
- Enhanced intestinal growth of Yersinia enterocolitica is suggested as a key factor.
- Damage to the intestinal mucosa likely facilitated the development of generalized infection.
Implications:
- Iron's role in promoting Yersinia enterocolitica growth warrants further investigation.
- The potential pathogenetic role of iron and desferrioxamine in such infections needs consideration.