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Related Experiment Videos

Weight and mortality in the Whitehall Study.

R J Jarrett, M J Shipley, G Rose

    British Medical Journal (Clinical Research Ed.)
    |August 21, 1982
    PubMed
    Summary
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    Mortality risk in middle-aged men varies by body mass index (BMI). While higher BMI correlated with increased all-cause mortality in younger men, older men with the lowest BMI faced higher risks, creating a J-shaped curve.

    Area of Science:

    • Epidemiology
    • Public Health
    • Gerontology

    Background:

    • The relationship between body mass index (BMI) and mortality is complex and may vary by age group.
    • Previous studies have indicated a linear association between higher BMI and increased mortality.
    • Understanding these age-specific associations is crucial for public health guidelines.

    Purpose of the Study:

    • To investigate the 10-year mortality rates in men aged 40-64 in relation to their body mass index (BMI).
    • To determine if the association between BMI and mortality differs across age strata within this cohort.
    • To explore potential confounding factors influencing the BMI-mortality relationship.

    Main Methods:

    • Analysis of 10-year mortality data from the Whitehall Study cohort.

    Related Experiment Videos

  • Stratification of participants by age groups (40-49 and 50-64 years).
  • Statistical analysis of all-cause mortality, cancer mortality, and coronary heart disease mortality in relation to BMI, adjusting for confounders like blood pressure, cholesterol, and smoking.

    • Main Results:

    • In men aged 40-49, all-cause mortality increased with higher BMI.
    • In men aged 50-64, the lowest BMI quintile showed increased mortality.
    • The overall "all-ages" mortality curve exhibited a "J" shape, not fully explained by confounders, with higher mortality in the lowest BMI quintile attributed partly to pre-existing cancers.

    Conclusions:

    • The association between BMI and mortality is age-dependent in middle-aged men.
    • A "J"-shaped mortality curve suggests that both underweight and overweight/obesity can be detrimental to health.
    • Public health strategies should consider age-specific BMI-mortality relationships, particularly for non-cancer, non-CHD causes in leaner individuals.