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Bromocryptin and epimestrol in MAP-negative secondary amenorrheas
Clinical and Experimental Obstetrics & Gynecology
|January 1, 1981
Summary
This study found that a combined treatment of Bromocryptine and Epimestrol effectively restored menstrual cycles and ovulation in young women with secondary amenorrhea. Hormonal analysis revealed increased levels of Gonadotropins and Estradiol after treatment.
Area of Science:
- Reproductive Endocrinology
- Gynecology
Background:
- Secondary amenorrhea affects women of reproductive age.
- Normoprolactinemic amenorrhea can be challenging to treat.
- Previous treatments with Epimestrol alone were insufficient for some patients.
Purpose of the Study:
- To evaluate the efficacy of a combined treatment for normoprolactinemic secondary amenorrhea.
- To assess the impact of Bromocryptine and Epimestrol on menstrual cycle restoration and ovulation.
Main Methods:
- 18 patients (18-24 years) with normoprolactinemic secondary amenorrhea were treated.
- A five-cycle combined treatment of Bromocryptine and Epimestrol was administered.
- Hormonal levels (FSH, LH, E2, PRL), progesterone, and basal temperature were monitored.
Main Results:
- Menstrual flow appeared in all patients after the third treatment cycle.
- Ovulation was observed in 13 out of 18 patients.
- Significant increases in Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), and Estradiol (E2) levels were noted.
Conclusions:
- Combined Bromocryptine and Epimestrol treatment is effective for normoprolactinemic secondary amenorrhea.
- The treatment successfully induces menstruation and ovulation in a majority of patients.
- Hormonal changes indicate improved hypothalamic-pituitary-ovarian axis function.