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Skeletal changes associated with copper deficiency.

T M Allen, A Manoli, R L LaMont

    Clinical Orthopaedics and Related Research
    |August 1, 1982
    PubMed
    Summary
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    Copper deficiency in premature infants on hyperalimentation can cause bone abnormalities, anemia, and neutropenia. Supplementation prevents and treats these serious conditions, improving infant health.

    Area of Science:

    • Biochemistry
    • Pediatric Nutrition
    • Hematology

    Background:

    • Premature infants on hyperalimentation are at risk for specific nutritional deficiencies.
    • Copper deficiency can manifest with significant hematological and skeletal complications.

    Observation:

    • Generalized bony abnormalities, anemia, and neutropenia were observed in infants receiving total parenteral nutrition.
    • These symptoms occurred despite normal levels of other essential minerals and vitamins.

    Findings:

    • Infants presented with low serum copper and ceruloplasmin levels.
    • Copper deficiency-related bone changes were preventable with increased copper supplementation.
    • Therapeutic copper supplements rapidly improved established bone abnormalities.

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    Implications:

    • Highlights the critical role of adequate copper levels in premature infants receiving parenteral nutrition.
    • Suggests proactive copper monitoring and supplementation protocols for at-risk infant populations.
    • Underscores the reversibility of bone and hematological issues with timely copper intervention.