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Related Experiment Videos

Plasminogen in human saliva.

G H Moody

    International Journal of Oral Surgery
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Saliva contains plasminogen, a key protein for dissolving blood clots. This finding suggests a natural system for wound healing in the mouth, preventing persistent fibrin clots on the oral mucosa.

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    Area of Science:

    • Biochemistry
    • Oral Biology
    • Physiology

    Background:

    • Plasminogen is a crucial protein involved in the fibrinolytic system, responsible for breaking down blood clots.
    • The presence and function of plasminogen in human saliva are not fully understood.
    • Understanding salivary plasminogen is important for comprehending oral mucosal health and wound healing.

    Purpose of the Study:

    • To investigate the presence and levels of plasminogen in different human saliva types (parotid, submandibular, whole).
    • To determine the origin of plasminogen in whole saliva.
    • To explore the implications of salivary plasminogen for in vivo fibrinolysis in the oral mucosa.

    Main Methods:

    • Immunological and functional assays were used to detect and quantify plasminogen in human parotid, submandibular, and whole saliva.

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  • Streptokinase was employed to activate plasminogen.
  • Centrifugation was performed on whole saliva samples to assess the contribution of cellular components to plasminogen levels.

    • Main Results:

    • Plasminogen was detected in parotid, submandibular, and whole saliva.
    • Whole saliva exhibited significantly higher plasminogen levels compared to parotid or submandibular saliva.
    • Centrifugation removed cellular components (leukocytes, epithelial cells) from whole saliva, largely eliminating the observed differences in plasminogen levels, indicating that plasminogen is primarily secreted into saliva rather than originating from these cells.

    Conclusions:

    • Plasminogen is predominantly secreted into saliva.
    • The oral mucosa likely possesses a robust plasminogen-assisted in vivo fibrinolysis system.
    • This intrinsic fibrinolytic capacity may explain the rarity of persistent fibrin clots on the oral mucosa.