[Sustak pharmacodynamics in effort stenocardia]

Area of Science:

• Cardiology
• Pharmacology

Background:

• Stable angina pectoris of effort is a common condition characterized by chest pain during physical exertion.
• Understanding the pharmacodynamics of antianginal drugs is crucial for optimizing patient treatment.

Purpose of the Study:

• To investigate the pharmacodynamics of Sustak in patients with stable angina pectoris.
• To evaluate the dose-dependent effects and patient variability in response to Sustak.

Main Methods:

• A double-blind, placebo-controlled study involving 32 patients with stable angina pectoris.
• Acute exercise tests were administered at regular intervals after dosaged physical exercises.
• Pharmacodynamic parameters, including ST segment depression, pain syndrome, arterial pressure, and pulse rate, were monitored.

Main Results:

• Sustak demonstrated a significant antianginal effect, reducing ST segment depression by 54% and alleviating pain one hour after a 6.4 mg dose.
• The drug induced a statistically significant reduction in arterial pressure and altered pulse rate dynamics during rest and exercise.
• Individual patient responses to Sustak varied considerably in duration and intensity.

Conclusions:

• Sustak exhibits notable antianginal properties, particularly in patients with reduced exercise tolerance or accompanying dyspnea.
• The drug's efficacy is evident in objective measures like ST segment depression and subjective pain relief.
• Personalized dosing and patient selection may enhance the therapeutic benefits of Sustak.