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07:23
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
'The analgesic abuse syndrome': an epidemiological perspective
International Journal of Epidemiology
|June 1, 1978
Summary
Excessive mild analgesic use can lead to chronic kidney failure. This study found no distinct "analgesic abuse syndrome" beyond high consumption, suggesting prevention efforts should focus on quantity, not other factors.
Area of Science:
- Pharmacology
- Nephrology
- Public Health
Background:
- Mild analgesics are widely accessible and generally safe.
- However, excessive intake can result in chronic renal failure.
- A concept of an analgesic abuse syndrome, distinct from intake quantity, has been proposed.
Purpose of the Study:
- To investigate the validity of an
- analgesic abuse syndrome
- by examining population-based analgesic consumption patterns.
- To identify factors associated with high analgesic intake beyond mere quantity.
Main Methods:
- A population study was conducted to analyze analgesic consumption.
- Consumption data was assessed for associations with social class, marital status, employment, and lifestyle factors (tea/coffee, smoking).
Main Results:
- Analgesic consumption distribution was unimodal, showing no distinct subgroup indicative of a syndrome.
- No significant associations were found between analgesic quantity and social class, marital status, employment, tea/coffee intake, or smoking.
- The primary determinants of higher analgesic intake were female sex and the presence of painful conditions.
Conclusions:
- Analgesic abuse is best defined by the quantity of analgesics consumed.
- The concept of a separate analgesic abuse syndrome is not useful for designing preventive programs.
- Prevention strategies should focus on limiting excessive analgesic consumption.
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