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Evaluation of Prl secretion in elderly subjects
Acta Endocrinologica
|July 1, 1982
Summary
Elderly women showed impaired prolactin (Prl) secretion in response to certain drugs, unlike elderly men. However, most elderly individuals maintained normal sleep-related prolactin patterns, suggesting good pituitary function in aging.
Area of Science:
- Endocrinology
- Gerontology
- Neuroendocrinology
Background:
- Prolactin (Prl) secretion regulation is complex and may change with aging.
- Understanding age-related alterations in hormone secretion is crucial for geriatric health.
Purpose of the Study:
- To investigate prolactin secretion patterns in elderly individuals.
- To assess the impact of aging on prolactin response to various stimuli.
Main Methods:
- Evaluated prolactin secretion in 76 elderly patients (71-86 years) under basal conditions.
- Administered TRH, sulpiride, and levodopa to assess drug-induced prolactin response.
- Monitored serum prolactin levels over a 24-hour period, including sleep-related changes.
Main Results:
- Elderly women exhibited an impaired prolactin response to TRH, sulpiride, and levodopa.
- Elderly men did not show an impaired prolactin response to the administered drugs.
- The majority of elderly subjects displayed normal sleep-related serum prolactin variations.
Conclusions:
- The pituitary gland appears capable of maintaining adequate prolactin secretory patterns in the elderly.
- Age-related differences in prolactin response to pharmacological stimuli exist between elderly men and women.