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Systemic anaphylaxis immediately following delayed hypersensitivity skin tests
Annals of Allergy
|September 1, 1982
Summary
Systemic anaphylaxis, a severe allergic reaction, can occur during delayed hypersensitivity skin testing, even in healthy individuals. Immediate treatment availability is crucial for patient safety during these common immunologic diagnostic procedures.
Area of Science:
- Immunology
- Allergy and Clinical Immunology
- Dermatology
Background:
- Delayed hypersensitivity skin testing is a common diagnostic tool, often used beyond primary immunologic conditions.
- While generally safe, the potential for adverse reactions necessitates careful consideration of patient risk factors.
Observation:
- A rare case of systemic anaphylaxis was observed during routine delayed hypersensitivity skin testing.
- The affected individual was healthy and had no history of atopy (allergic predisposition).
Findings:
- The anaphylactic reaction was determined to be IgE-mediated, indicating a classic allergic response pathway.
- This suggests that even individuals without known allergies can experience severe hypersensitivity reactions.
Implications:
- Healthcare providers must be prepared for potential anaphylaxis during delayed hypersensitivity skin testing.
- Availability of anaphylactic recovery sets and emergency protocols is essential for patient safety in clinical settings.