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Pyoderma gangrenosum associated with primary thrombocythaemia.
British Medical Journal (Clinical Research Ed.)
|September 25, 1982
Summary
Pyoderma gangrenosum can be linked to blood disorders, not just inflammatory bowel disease or rheumatoid arthritis. This case highlights a patient whose leg ulcer recurred and was diagnosed as pyoderma gangrenosum associated with primary thrombocythaemia.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Pyoderma gangrenosum (PG) is a neutrophilic dermatosis often associated with systemic conditions.
- While commonly linked to inflammatory bowel disease (IBD) and rheumatoid arthritis (RA), PG has also been reported in association with hematological malignancies.
Observation:
- A 54-year-old man presented with a leg ulcer, initially treated successfully.
- Bone marrow aspiration revealed findings consistent with primary thrombocythaemia.
Findings:
- The patient experienced a significant recurrence of ulceration seven weeks later.
- The recurrent condition was diagnosed as pyoderma gangrenosum.
Implications:
- This case underscores the association between pyoderma gangrenosum and hematological disorders, specifically primary thrombocythaemia.
- The clinical presentation of PG in the context of blood disorders may differ from that seen in IBD or RA patients.