Clinical and histological changes following cryotherapy in a case of widespread oral leukoplakia

The effects of cryotherapy on widespread leukoplakia of the buccal and vestibular mucosa were observed clinically and studied histologically. The treated areas were clinically normal 2 months after treatment, and discomfort and inconvenience of treatment were minimal. The epithelium, which was initially orthokeratinized, with mild dysplasia, and which was almost entirely lacking in glycogen, reverted to the parakeratinized or non-keratinized form, with normal distribution of glycogen in the stratum spinosum.