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11:56
A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
Published on: April 11, 2014
Vitamin C requirements in postoperative patients
International Journal for Vitamin and Nutrition Research. Supplement = Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Supplement
|January 1, 1982
Summary
Postoperative surgery significantly reduces ascorbic acid (vitamin C) levels in patients. Increased requirements and lower white blood cell vitamin C content suggest supplementation may be beneficial.
Area of Science:
- Biochemistry
- Clinical Nutrition
- Surgical Research
Background:
- Ascorbic acid (vitamin C) plays a crucial role in cellular functions and tissue repair.
- Surgical stress can impact nutrient metabolism and requirements.
- Understanding postoperative ascorbic acid status is important for patient recovery.
Purpose of the Study:
- To assess postoperative ascorbic acid requirements in surgical patients.
- To investigate the relationship between ascorbic acid levels and other postoperative markers.
- To evaluate the potential need for ascorbic acid supplementation after surgery.
Main Methods:
- Measured buffy layer leucocyte ascorbic acid and white blood cell ascorbic acid content in 63 surgical patients.
- Analyzed changes in ascorbic acid levels relative to surgical trauma and blood transfusion volume.
- Correlated postoperative ascorbic acid measurements with white blood cell counts.
Main Results:
- A significant reduction in ascorbic acid levels was observed post-surgery.
- Postoperative changes in ascorbic acid were not linked to surgical trauma extent or blood transfusion volume.
- A significant correlation was found between postoperative ascorbic acid levels and white blood cell counts.
- Leukocytosis and the release of white blood cells with lower ascorbic acid content may contribute to observed reductions.
- A 42% reduction in circulating white blood cell ascorbic acid was noted by the third postoperative day.
Conclusions:
- Surgical operations lead to an authentic increase in ascorbic acid requirements.
- Findings support the consideration of ascorbic acid supplementation for surgical patients.
- Postoperative changes in leucocyte ascorbic acid are unlikely to have pathological significance in wound repair.
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