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Related Experiment Videos

Vitamin C-aspirin interactions.

T K Basu

    International Journal for Vitamin and Nutrition Research. Supplement = Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Supplement
    |January 1, 1982
    PubMed
    Summary
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    Aspirin may reduce vitamin C absorption in humans and guinea pigs. Studies show that taking aspirin with vitamin C hinders the body's ability to absorb this essential nutrient.

    Area of Science:

    • Biochemistry
    • Human Physiology
    • Pharmacology

    Background:

    • Vitamin C (ascorbic acid) is an essential nutrient crucial for various bodily functions.
    • Aspirin (acetylsalicylic acid) is a widely used nonsteroidal anti-inflammatory drug.
    • Potential interactions between common medications and nutrient absorption warrant investigation.

    Purpose of the Study:

    • To investigate the effect of soluble aspirin on vitamin C availability in humans and guinea pigs.
    • To determine if co-administration of aspirin impacts vitamin C absorption and excretion.
    • To elucidate the mechanism by which aspirin might affect vitamin C uptake.

    Main Methods:

    • Human study: Oral administration of vitamin C (500 mg) alone and with aspirin (900 mg), measuring plasma, leucocyte, and urine vitamin C levels.

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  • Guinea pig study: Similar administration protocols, with additional measurement of fecal vitamin C excretion.
  • In vitro study: Everted gut sac preparations to assess the effect of acetylsalicylate on vitamin C uptake across the intestinal wall.

    • Main Results:

    • In humans, aspirin co-administration blocked the expected increase in plasma, leucocyte, and urine vitamin C concentrations.
    • In guinea pigs, aspirin increased fecal vitamin C excretion, indicating reduced absorption.
    • In vitro studies demonstrated that acetylsalicylate significantly lowered the vitamin C concentration gradient and intestinal uptake.

    Conclusions:

    • Aspirin appears to impede the gastrointestinal absorption of vitamin C.
    • This interaction may be significant for individuals with borderline vitamin C intake.
    • Further research may be needed to establish clinical recommendations regarding concurrent aspirin and vitamin C use.