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Related Experiment Videos

pH-sensitive microcapsules for drug release.

K Bala, P Vasudevan

    Journal of Pharmaceutical Sciences
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This study developed pH-sensitive microcapsules for sustained drug release, demonstrating zero-order kinetics for secretin delivery. These findings suggest potential applications in treating duodenal ulcers and diagnosing pancreatic diseases.

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    Area of Science:

    • Biomaterials Science
    • Drug Delivery Systems
    • Polymer Chemistry

    Background:

    • Developing controlled drug release systems is crucial for effective therapeutic outcomes.
    • External stimuli-responsive materials offer precise control over drug release kinetics.
    • Secretin, a peptide hormone, has diagnostic and therapeutic relevance.

    Purpose of the Study:

    • To design and characterize pH-sensitive microcapsules for sustained drug release.
    • To investigate the release kinetics of encapsulated secretin in response to varying pH levels.
    • To explore the potential applications of these microcapsules in treating duodenal ulcers and diagnosing pancreatic diseases.

    Main Methods:

    • Acryloyl chloride-lysine microcapsules were synthesized encapsulating secretin.

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  • Scanning electron microscopy (SEM) was used to analyze microcapsule morphology and size (5-10 microns).
  • Drug release studies were conducted in four different pH media to assess release profiles.

    • Main Results:

    • Spherical microcapsules with good morphology were successfully fabricated.
    • Microcapsule dissolution and secretin release were found to be pH-sensitive.
    • Zero-order drug release kinetics were observed in polymer buffer media, with erosion rates dependent on pH.

    Conclusions:

    • Acryloyl chloride-lysine microcapsules provide a pH-controlled, sustained release system for secretin.
    • The pH-sensitive nature of these microcapsules enables tunable drug delivery.
    • This technology holds promise for targeted therapies and diagnostic applications in gastroenterology.