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Related Experiment Videos

Bicarbonate concentrations in the renal cortex.

J L Gamble, A M Skoff

    Renal Physiology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Rat renal cortex tissue shows total carbon dioxide (CO2) levels that vary significantly with metabolic changes. These findings suggest potential alterations in intracellular CO2 concentrations during metabolic disorders.

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    Area of Science:

    • Physiology
    • Biochemistry

    Background:

    • Carbon dioxide (CO2) plays a crucial role in cellular processes.
    • Understanding intracellular CO2 concentrations is vital for metabolic research.

    Purpose of the Study:

    • To measure total CO2 concentration in rat renal cortex tissue.
    • To investigate the impact of physiological and pharmacological interventions on renal CO2 levels.

    Main Methods:

    • Quick-frozen rat renal cortex samples were used.
    • Alkaline extracts were analyzed for total CO2 (CO2 + HCO3-) concentration.
    • Measurements were compared between plasma water and tissue water.

    Main Results:

    • Mean total CO2 concentration in renal cortex tissue water was 18.7 mEq/l, lower than plasma water (23.5 mEq/l).

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  • Benzolamide administration increased tissue CO2 to 28.3 mEq/l; NaHCO3 infusion raised it to 38.1 mEq/l.
  • Hyperventilation or HCl infusion decreased tissue CO2 to 14-15 mEq/l.

    • Conclusions:

    • Rat renal cortex intracellular CO2 concentration is estimated at 20-25 mEq/l, approximately double that of skeletal muscle.
    • Renal CO2 levels exhibit significant variability, indicating potential alterations in metabolic disorders.