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Related Experiment Videos

Thyroid associated components in serum during normal pregnancy.

L Skjöldebrand, J Brundin, A Carlström

    Acta Endocrinologica
    |August 1, 1982
    PubMed
    Summary

    Thyroid hormone levels change significantly during pregnancy. Thyroxine-binding globulin (TBG) and thyroxine (T4) increase, while free-T4 decreases, with thyroid-stimulating hormone (TSH) rising late in pregnancy.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Clinical Biochemistry

    Background:

    • Thyroid hormones are crucial for maternal and fetal health during pregnancy.
    • Understanding dynamic changes in thyroid-binding proteins and hormones is essential for accurate interpretation of thyroid function tests in pregnant individuals.

    Purpose of the Study:

    • To comprehensively analyze the longitudinal changes of key thyroid-related proteins and hormones throughout normal pregnancy.
    • To establish normative reference ranges for these parameters at different gestational stages.

    Main Methods:

    • Longitudinal study involving 290 pregnant individuals.
    • Measurements of thyroxine-binding globulin (TBG), thyroxine-binding pre-albumin (TBPA), total thyroxine (T4), free-T4, triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were performed at 2-week intervals.

    Main Results:

    • TBG levels increased and plateaued by the 24th week.
    • T4 levels rose until the 16th week, then stabilized.
    • Free-T4 levels decreased significantly, reaching near-subnormal levels around the 20th week.
    • T3 showed an initial increase, stabilizing after the 14th week.
    • TSH levels increased towards the end of pregnancy, peaking in the last 4 weeks.
    • TBPA levels remained constant throughout pregnancy.

    Conclusions:

    • Pregnancy is associated with distinct dynamic alterations in thyroid hormone transport proteins and hormones.
    • These findings provide valuable data for the interpretation of thyroid function tests in pregnant populations.
    • The study highlights the need for pregnancy-specific reference ranges for accurate diagnosis and management.

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