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Skeletal muscle function in malnutrition.

J Lopes, D M Russell, J Whitwell

    The American Journal of Clinical Nutrition
    |October 1, 1982
    PubMed
    Summary
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    Malnutrition impairs skeletal muscle function, causing increased fatigue and altered contraction/relaxation patterns. Nutritional supplementation can reverse these effects, improving muscle performance.

    Area of Science:

    • Physiology
    • Nutrition Science
    • Clinical Medicine

    Background:

    • Malnutrition significantly impacts overall health, including skeletal muscle function.
    • Gastrointestinal disorders can exacerbate malnutrition and its systemic effects.
    • Assessing objective muscle function is crucial for understanding malnutrition's impact.

    Purpose of the Study:

    • To evaluate skeletal muscle function in malnourished patients with gastrointestinal disorders.
    • To compare muscle function parameters between malnourished patients and healthy controls.
    • To assess the reversibility of muscle dysfunction through nutritional support.

    Main Methods:

    • Assessed adductor pollicis muscle function via ulnar nerve electrical stimulation.
    • Measured force of contraction at various frequencies (10-100 Hz).

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  • Quantified maximal relaxation rate and muscle endurance.

    • Main Results:

    • Malnourished patients exhibited higher contraction force at 10 Hz (43.0% vs. 28.8%).
    • Patients showed slower maximal relaxation rates (7.2% vs. 9.6%) and increased force loss during endurance testing (29.1% vs. 3.5%).
    • Four weeks of total parenteral nutrition significantly improved muscle function parameters.

    Conclusions:

    • Malnutrition leads to increased muscle fatiguability and altered contraction/relaxation dynamics.
    • These functional deficits are reversible with nutritional supplementation.
    • The assessed technique is valuable for evaluating malnutrition's functional consequences and treatment response.