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Related Experiment Videos

Semiautomated method for determining ferrous sulfate in pharmaceuticals: collaborative study.

P A McCullen

    Journal - Association of Official Analytical Chemists
    |July 1, 1978
    PubMed
    Summary

    A new semiautomated colorimetric method accurately determines ferrous sulfate in various pharmaceutical forms. This reliable method for ferrous sulfate analysis has been officially adopted.

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    Area of Science:

    • Pharmaceutical Chemistry
    • Analytical Chemistry

    Background:

    • Accurate quantification of ferrous sulfate (FeSO4) is crucial for pharmaceutical quality control.
    • Existing methods may have limitations in speed or applicability to diverse dosage forms.

    Purpose of the Study:

    • To describe and validate a semiautomated colorimetric method for ferrous sulfate determination.
    • To assess the method's applicability to tablets, capsules, and elixirs.

    Main Methods:

    • Utilized a colorimetric approach forming an orange-red complex with 1,10-phenanthroline and ferrous ions.
    • Tested the method on solid composites (tablets, capsules) and a liquid elixir sample.
    • Compared results with the official United States Pharmacopeia (USP) method.

    Main Results:

    • The semiautomated method demonstrated good agreement with the USP method for ferrous sulfate quantification.
    • No significant interference was observed from ferric iron or common tablet colorings (red, green).
    • The method proved effective for analyzing ferrous sulfate in tablets, capsules, and elixirs.

    Conclusions:

    • The described semiautomated colorimetric method provides a reliable and efficient means for ferrous sulfate analysis.
    • Its adoption as official first action highlights its suitability for pharmaceutical quality control.
    • The method offers a robust alternative for quantifying ferrous sulfate in various medicinal formulations.

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