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Long-term survival after cadaveric renal transplantation
British Medical Journal (Clinical Research Ed.)
|October 23, 1982
Summary
Cadaveric kidney transplantation offers long-term treatment for chronic renal failure. Patient survival has improved, making kidney transplants increasingly acceptable for patients needing renal replacement therapy.
Area of Science:
- Nephrology
- Transplantation Immunology
- Surgical Innovation
Background:
- Chronic renal failure necessitates renal replacement therapy.
- Cadaveric kidney transplantation has been a significant treatment modality since 1967.
- Long-term outcomes of cadaveric kidney transplantation require ongoing evaluation.
Purpose of the Study:
- To evaluate the long-term patient and graft survival rates for cadaveric kidney transplants.
- To assess the trends in patient and graft survival over time.
- To determine the efficacy of cadaveric transplantation as a sustained treatment for end-stage renal disease.
Main Methods:
- Analysis of actuarial survival data for 404 first cadaver kidney transplants.
- Evaluation of graft function at five and 10-year intervals.
- Comparison of outcomes for first and second cadaver kidney transplants.
Main Results:
- Actuarial five- and 10-year patient survival rates were 61% and 47%, respectively.
- Actuarial five- and 10-year graft survival rates were 46% and 36%, respectively.
- Patient survival improved over time, while graft survival remained static; outcomes for second transplants were similar to first transplants.
Conclusions:
- Cadaveric kidney transplantation demonstrates long-term viability for managing chronic renal failure.
- Improved patient survival enhances the overall acceptability of cadaveric kidney transplantation.
- The procedure remains a crucial option for renal replacement therapy.