[Characteristics of membrane and plasma proteins in the spontaneously hypertensive rat]

The red blood cell membrane proteins and plasma proteins of normal and spontaneous hypertensive Rats were studied by uni- and bidimentional polyacrylamide gel electrophoresis. The amount of band 3 was observed to be significantly reduced in the red blood cell membrane of spontaneously hypertensive Rats. Plasma from these Rats contained two additional heatstable proteins, characterized by a molecular weight of 16,000 dalton and isoelectric points of 4.7 and 5.1. These changes may constitute biochemical changes genetically associated with hypertension.