[Estrogen secretion by the chick embryo ovary after taxomifen treatment]

The question was posed whether tamoxifen, an anti-oestrogen had any effect on the oestrogen secretion by the Chick embryo ovary. The synthesis of oestrone and oestradiol from radiolabelled progesterone was taken as a measure of oestrogen secretion, and it was found that there was no variation. The structural changes observed by Salzgeber, Reyss-Brion and Baulieu [1] and by Scheib and Baulieu [2] may be explained by the action of tamoxifen on effector cells.