Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental changes in pituitary-thyroid function in the human fetus and newborn.

A H Klein, T H Oddie, M Parslow

    Early Human Development
    |September 1, 1982
    PubMed
    Summary

    Thyroid hormone levels in newborns mature significantly with gestational age, indicating a changing feedback control system in premature infants. This maturation continues until two months of life.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development and Interrogation of a Transcriptomic Resource for the Giant Triton Snail (Charonia tritonis).

    Marine biotechnology (New York, N.Y.)·2021
    Same author

    Thermosensitive transient receptor potential (TRP) channel agonists and their role in mechanical, thermal and nociceptive sensations as assessed using animal models.

    Chemosensory perception·2015
    Same author

    Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses.

    Neuroscience·2014
    Same author

    Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons.

    Neuroscience·2012
    Same author

    The casemix system of hospital funding can further disadvantage Aboriginal children.

    The Medical journal of Australia·1998
    Same author

    The Aboriginal and Torres Strait Islander casemix study.

    The Medical journal of Australia·1998

    Area of Science:

    • Endocrinology
    • Neonatal Physiology
    • Developmental Biology

    Background:

    • The hypothalamic-pituitary-thyroid (HPT) axis undergoes significant development during gestation and early infancy.
    • Understanding thyroid hormone regulation in premature infants is crucial for assessing their health and development.

    Purpose of the Study:

    • To assess the maturation of the HPT axis in premature and full-term infants.
    • To correlate thyroid hormone concentrations with gestational age, sex, and birthweight.
    • To compare neonatal thyroid hormone levels with those of older infants and adults.

    Main Methods:

    • Measurements of thyroxine (T4), free T4 (FT4), thyrotropin (TSH), and thyroxine-binding globulin (TBG) in cord serum.
    • Correlation analysis with gestational age, sex, and birthweight.

    Related Experiment Videos

  • Comparison with data from 2-month-old infants and adults.

    • Main Results:

    • Significant increases in T4, FT4, and TBG were observed with increasing gestational age from 26 to 33-35 weeks.
    • After 34 weeks of gestation, these hormone levels did not vary significantly with gestational age.
    • The FT4/TSH ratio increased with gestational age and was lower in cord blood compared to older infants and adults.

    Conclusions:

    • The set point for negative feedback control of TSH secretion changes between 26 weeks gestation and 2 months of life.
    • Thyroid gland sensitivity to TSH stimulation appears to increase between 26 and 33 weeks gestation.
    • These findings highlight the dynamic maturation of the HPT axis in early life.