[Tolerability of pirprofen during prolonged treatment]

During a non-comparative multicentric study, 70 patients suffering from various rheumatological diseases were treated by pirprofen for an average duration of 32 weeks (from 1 to 121 weeks). The daily dose varied from 400 to 1200 mg. Efficacy was judged good or excellent in 53 of the 70 patients (75%). Side effects, especially digestive, were noted in 27 patients (38%). They only caused discontinuation of treatment in 9 patients (13%). Amongst the 38 side effects, 26 occurred during the first 8 weeks of treatment. Despite the long duration of the treatment, the overall tolerance of pirprofen was good or acceptable in 87,5% of patients. The very high level of compliance in this long-term treatment attests to the good tolerance of pirprofen.