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Serum apolipoproteins A-I, A-II and B in diabetic children and matched healthy controls
Insights
Diabetic children show higher serum apolipoprotein A-I levels than healthy children. Correlations between apolipoproteins and serum lipids differ in diabetic versus healthy children.
Area of Science:
- Pediatric Endocrinology
- Clinical Biochemistry
- Lipid Metabolism
Background:
- Diabetes mellitus in children can affect lipid profiles.
- Apolipoproteins are crucial components of lipoproteins and play roles in lipid transport.
- Understanding apolipoprotein levels in pediatric diabetes is important for assessing cardiovascular risk.
Purpose of the Study:
- To compare serum concentrations of apolipoprotein A-I (apo A-I), apolipoprotein A-II (apo A-II), and apolipoprotein B (apo B) in diabetic children and healthy controls.
- To investigate the correlations between apolipoproteins and serum lipids in both groups.
Main Methods:
- Serum samples were collected from 28 diabetic children (ages 3-16) and 14 healthy matched controls.
- Concentrations of apo A-I, apo A-II, and apo B were measured.
- Serum cholesterol levels were also determined.
- Statistical analyses were performed to compare groups and assess correlations.
Main Results:
- Diabetic children had significantly higher serum apo A-I concentrations compared to healthy children (p < 0.02).
- Serum apo A-II and apo B concentrations did not significantly differ between diabetic and healthy children.
- In healthy children, serum cholesterol strongly correlated with apo A-I and apo A-II.
- These correlations were not observed in diabetic children, suggesting altered apolipoprotein/lipoprotein lipid relationships.
Conclusions:
- Pediatric diabetes is associated with elevated serum apo A-I levels.
- The relationship between apolipoproteins and serum lipids appears altered in diabetic children compared to their healthy peers.
- Further research is warranted to elucidate the implications of these altered lipid-apolipoprotein interactions in pediatric diabetes.
Abstract:
Serum concentrations of apolipoprotein (apo) A-I. A-II and B were determined in 28 diabetic children (age 3-16 years) and 14 healthy matched controls. In the healthy children the serum apo A-I concentration was 120 +/- 20 arbitrary units (A.U.) (mean +/- S.D.), apo A-II 111 +/- 14 A.U. and apo B 100 +/- 34 A.U. (100 A.U. = mean concentration in adult blood donors). The apo A-I concentration was significantly higher in the diabetic children (134 +/- 13; p less than 0.02) than in the healthy controls. In diabetics apo A-II was 116 +/- 14 A.U. and apo B 106 +/- 21 A.U., values not significantly different from those in the controls. The serum cholesterol concentration in the healthy children correlated strongly to apo A-I and apo A-II, which was not the case in the diabetics. The differences between diabetic and healthy children with respect to correlations between the apolipoproteins and the serum lipids might indicate a different apolipoprotein/lipoprotein lipid relationship in diabetics.