Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tomographic abnormalities simulating pituitary microadenomas.

G Wortzman, N B Rewcastle

    AJNR. American Journal of Neuroradiology
    |September 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reovirus as an experimental therapeutic for brain and leptomeningeal metastases from breast cancer.

    Gene therapy·2004
    Same author

    How often are nonenhancing supratentorial gliomas malignant? A population study.

    Neurology·2002
    Same author

    Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas.

    British journal of cancer·2001
    Same author

    Reovirus as an oncolytic agent against experimental human malignant gliomas.

    Journal of the National Cancer Institute·2001
    Same author

    Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas.

    Neuro-oncology·2001
    Same author

    Acute quadriplegic myopathy unrelated to steroids or paralyzing agents: quantitative EMG studies.

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·1999
    Same journal

    Neuroradiology Leads NIH Funding Among Clinician Diagnostic Radiologists: A 14-Year National Analysis.

    AJNR. American journal of neuroradiology·2026
    Same journal

    Neutral Cervical Spine MRI is Not Enough: The Critical Role of Flexion Imaging in Hirayama disease in Pediatric Patients.

    AJNR. American journal of neuroradiology·2026
    Same journal

    CT Evaluation of Osseous Trauma at the Craniocervical Junction: A Pattern-Based Overview.

    AJNR. American journal of neuroradiology·2026
    Same journal

    Comprehensive Structural MRI Phenotyping in <i>Oligophrenin 1-</i>Related Disorder Reveals Characteristic Brain Malformations.

    AJNR. American journal of neuroradiology·2026
    Same journal

    ASNR-ESNR White Paper on Sustainability in Neuroradiology.

    AJNR. American journal of neuroradiology·2026
    Same journal

    Intracranial Atherosclerotic Disease Distribution Across Circle of Willis Segments: Insights from CREST-H.

    AJNR. American journal of neuroradiology·2026
    See all related articles

    Sellar tomography can misinterpret pituitary microadenomas. Minor bony variations, often due to normal anatomy like posterior lobe asymmetry, can mimic abnormalities, necessitating cautious interpretation of sellar tomograms.

    Area of Science:

    • Radiology
    • Endocrinology
    • Anatomy

    Background:

    • Sellar tomography is used to detect pituitary microadenomas.
    • Abnormalities in sellar tomograms can lead to misinterpretations.

    Purpose of the Study:

    • To investigate the causes of false-positive and false-negative interpretations in sellar tomography for pituitary microadenomas.
    • To correlate bony variations of the sella with the presence of pituitary microadenomas.

    Main Methods:

    • Autopsy study correlating sellar tomograms with pituitary microadenomas.
    • Analysis of bony variations in 120 sellas.
    • In situ study of 50 pituitary glands to assess posterior lobe asymmetry.

    Main Results:

    Related Experiment Videos

  • Approximately one-fifth of sellar tomograms showed false-positive or false-negative results for pituitary microadenomas.
  • Minor bony variations (e.g., asymmetry, empty sella) were found in 27/120 sellas.
  • Posterior lobe asymmetry, a common anomaly (76%), significantly contributes to sellar asymmetry.

    • Conclusions:

    • Minor radiologic criteria for pituitary microadenoma must be interpreted cautiously.
    • Sellar asymmetry and other bony variations often result from explainable anatomic causes, not necessarily microadenomas.
    • Clinical and biochemical data are crucial for accurate diagnosis in the presence of ambiguous sellar tomograms.