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Pancreas transplantation.

D E Sutherland, F C Goetz, J S Najarian

    Clinics in Endocrinology and Metabolism
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Pancreas transplants can help insulin-dependent diabetic patients achieve insulin independence. However, graft rejection remains a significant challenge, limiting wider application of this treatment.

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    Area of Science:

    • Transplantation Immunology
    • Endocrinology
    • Metabolic Surgery

    Background:

    • Insulin-dependent diabetes mellitus (IDDM) is a chronic metabolic disorder requiring lifelong insulin therapy.
    • Pancreas transplantation aims to restore endogenous insulin production and normalize glucose metabolism.
    • Over 170 patients underwent pancreas transplantation between 1966 and 1981 to address the metabolic defect in IDDM.

    Purpose of the Study:

    • To evaluate the outcomes of pancreas transplantation in patients with insulin-dependent diabetes.
    • To identify the primary challenges and limitations of pancreas transplantation.

    Main Methods:

    • 183 pancreas transplants were performed between December 1966 and October 1981.
    • Various techniques were employed to manage exocrine pancreatic secretions, with synthetic polymer injection being most common.

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  • Patients received immunosuppression to prevent graft rejection.

    • Main Results:

    • Currently, 20 patients have functioning grafts and are insulin independent.
    • Twelve grafts functioned for over a year, with one lasting four years.
    • While carbohydrate metabolism improved in functioning grafts, graft rejection was the main cause of failure.

    Conclusions:

    • Pancreas transplantation can normalize carbohydrate metabolism in diabetic patients.
    • Graft rejection is the primary obstacle to successful pancreas transplantation.
    • Advancements in immunosuppression are crucial for expanding pancreas transplantation to a broader diabetic population.