[Long-term indomethacin treatment of ophthalmopathies after Basedow disease in general practice]

Seven patients with Basedow' disease were treated with 100 mg of indomethacin (rectal suppository) before going to bed and showed moderate improvement of various ocular disturbances. In two there was conspicuous regression of edema of the upper eyelid. In these patients a double eyelid hidden by the edema reappeared and the bloated sensation in the eyelid decreased. In two other patients, the edema and the bloated sensation in the eyelid decreased slightly. In two patients exophthalmus decreased by 1-2 mm. Diplopia disappeared in two patients and was improved in 1. Two patients failed to continue treatment with indomethacin suppositories, due to exacerbation of hemorrhoids. Indomethacin was moderately effective in treating Basedow's ophthalmopathy. The author believes that indomethacin is as efficacions as or more so than drugs tried so far for Basedow's ophthalmopathy.