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Related Experiment Videos

Antacids and pepsin.

A Berstad

    Scandinavian Journal of Gastroenterology. Supplement
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Common antacids with aluminium hydroxide gel bind to pepsin in the stomach. This precipitation, not inactivation, reduces measurable pepsin levels in gastric aspirates.

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    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Pepsin is a key enzyme in gastric digestion.
    • Antacids are frequently used to manage acid-related gastrointestinal disorders.

    Purpose of the Study:

    • To investigate the interaction between aluminium hydroxide gel antacids and pepsin.
    • To elucidate the mechanism behind reduced pepsin concentration observed in vivo.

    Main Methods:

    • In vitro assessment of adsorbent and precipitating effects of aluminium hydroxide gel on pepsin.
    • In vivo analysis of pepsin concentration in gastric aspirates following antacid administration.

    Main Results:

    • Aluminium hydroxide gel demonstrates significant adsorbent and precipitating effects on pepsin within a specific pH range.

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  • No direct inactivation of pepsin by the antacid was observed, apart from pH alteration.
  • Reduced pepsin concentration in vivo is likely due to precipitation and incomplete aspiration of the precipitated pepsin.

    • Conclusions:

    • Aluminium hydroxide antacids interact with pepsin via adsorption and precipitation, not direct inactivation.
    • The observed reduction in gastric pepsin levels post-antacid administration is attributed to physical binding and sedimentation.