[Isotope nephrography in studying the nephrotoxicity of cisplatin in pigs]

The cis-DDP (Cisplatin) nephrotoxicity and its prevention by hydration in experimental pigs was studied by laboratory and patho-morphological examinations and by isotope nephrography (renography). In total, 33 nephrographic examinations were performed in 14 pigs. The comparison of these nephrographs with the laboratory and post-mortem patho-morphological examinations showed that all findings were in perfect accordance. Only in exceptional cases there was a discrepancy between the pathological nephrograph and the type of kidney damage. The possibility of using the isotope nephrography as a progressive complementary method of the kidney function examination, under the condition of securing suitable maximum immobility of pigs, was fully proved.